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饮食,肠道微生物群和肝胆癌之间的因果关系的遗传证据:孟德尔的随机化研究

Runze Huang^1,2, Xin Jin^1,2, Qinyu Liu^1,2

¹Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China.

|July 4, 2025

概括

饮食显著影响肝脏和胆道癌,肠道微生物作为关键中间体. 了解这些联系可以导致针对微生物的食策略来预防癌症.

科学领域:

胃肠病学和肝病学
微生物组研究微生物组研究
癌症流行病学癌症流行病学

背景情况:

饮食习惯,肠道微生物群和肝胆癌越来越多地联系在一起.
这些因素之间的因果关系在很大程度上仍然不清楚.
遗传关联研究对于阐明这些复杂的相互作用至关重要.

研究的目的:

研究饮食成分,肠道微生物群和肝胆癌症风险之间的因果关系.
为了确定影响肝脏和胆道癌症的特定饮食和微生物因素.
探索肠道微生物群在饮食与癌症关联中的调解作用.

主要方法:

进行了全面的双样本门德尔随机化 (MR) 分析.
利用来自欧洲大型群体的遗传仪器.
对88种饮食成分,1080种微生物群特征,肝癌和胆道癌的相关性进行了评估.

主要成果:

在17种饮食和101种微生物特征与肝胆癌风险之间发现了显著的因果关系.
对11种饮食和70种微生物群特征观察到逆因果关系的证据.
一项两步的MR调解分析确定了43种微生物种群和6种代谢途径,它们调解了饮食对癌症风险的影响,其中Mollicutes RF9调解了对胆道癌症的保护作用.

结论:

肠道微生物群作为重要的中间体,将饮食摄入量与肝胆癌症风险联系起来.
针对微生物组的饮食策略显示出作为预防性干预措施的潜力.
需要进一步的研究来确认机制并开发向疗法.

关键词:

饮食摄入量饮食摄入量我们的肠道微生物群.肝胆癌是一种肝胆癌.门德尔的随机化

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