对患者特征,不良事件和巨细胞动脉炎患者的经济负担的现实世界分析,这些患者接受了葡萄糖皮质类药物治疗
Jeffrey R Curtis1, Denise T Kruzikas2, Ana Romero2
1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Shelby 121H, Birmingham, AL, 35294, USA. jrcurtis@uabmc.edu.
巨细胞动脉炎 (GCA) 患者新接受葡萄糖皮质类药物 (GCs) 治疗时,与GC相关的不良事件 (GRAE) 发生率显著增加,医疗费用增加一倍. 这凸显了GC在GCA管理中的大量医疗和财务负担.
科学领域:
- 类风湿病学 类风湿病学
- 药物经济学 药物经济学
- 临床流行病学 临床流行病学
背景情况:
- 巨细胞动脉炎 (GCA) 的管理通常涉及长期的葡萄糖皮质激素 (GC) 治疗.
- 长期使用GC与严重副作用和不良事件的风险增加有关.
- 评估GCA中GC相关不良事件 (GRAE) 的综合负担至关重要.
研究的目的:
- 评估GC患者使用GC的负担.
- 在11个临床类别中分析39种特定GRAE的发病率.
- 为了比较医疗保健资源利用率和GCA患者在GC和对照组之间的成本.
主要方法:
- 使用Merative MarketScan®数据库 (2009-2020) 进行的回顾性观察性研究.
- 确定年龄≥50岁的新诊断出GCA并开始接受GC治疗的患者.
- 在GC启动后的60个月内,将GCA+GC队列与两个对照队列 (没有GCA/没有GC;没有GCA) 进行比较.
主要成果:
- 与对照组相比,GCA+GC患者在39个评估的GRAE中表现出38个显著更高的GRAE率 (p<0.001).
- 在GRAEs的绝对差异范围从3% (肌肉骨) 到20% (骨相关).
- GCA+GC患者的住院率翻了一番,平均全因医疗费用 (37,936美元对12,498美元;p<0.001) 显著上升.
结论:
- 新诊断的GCA患者开始进行GC,在所有类别中经历显著增加的GRAE率.
- 与非GCA对照组相比,这些患者面临的医疗费用大约是医疗费用的两倍.
- 这些发现强调了与GCA中GC治疗相关的相当大的医疗和财务负担.
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