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Updated: Sep 16, 2025

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在多细胞性,人体健康和疾病中探索保存的上下文依赖的cis-regulatory元素 (cdCREs) 的作用

Andrew McEwan1, Alexander Rattray1, Greg Hutchings1

  • 1Institute of Medical Sciences, Foresterhill, University of Aberdeen, UK.

The FEBS journal
|July 4, 2025
PubMed
概括

情境依赖的 cis 调节元件 (cdCREs) 对于发育和健康中的基因调节至关重要. 了解它们在脊椎动物中的保存功能对于破译与疾病相关的非编码DNA变异至关重要.

关键词:
通过CRISPR进行基因组编辑.通过DNA甲基化.这是一个 cis-regulatory 元素.进行比较的基因组学.这是一个上下文依赖的背景.基因调节 基因调节 基因调节在体内活体模型中的模型.它们是多细胞多细胞的.

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