特拉佐对狗的心率,心率变化和QT间隔的影响
V T Silvia1, T C DeFrancesco2, K R Love3
1The Ohio State University College of Veterinary Medicine, 1900 Coffey Rd, Columbus, OH, 43210, USA.
概括
在狗中,特拉佐增加了心率 (HR) 和降低了心率变化 (HRV),但没有影响QT间隔 (QTi). 在研究期间,这种药物也改善了狗的平静.
科学领域:
- 兽医心脏病学 兽医心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 特拉佐是一种常见的药物,用于治疗狗的行为问题.
- 它对心率 (HR),心率变化 (HRV) 和QT间隔 (QTi) 等心血管参数的影响需要彻底调查.
研究的目的:
- 评估口服特拉佐对健康狗的HR,HRV和QTi的影响.
- 在狗模型中评估与特拉佐使用相关的行为变化.
主要方法:
- 一项双盲,安慰剂控制的交叉研究与20只健康的狗进行.
- 狗接受了24小时的特拉佐 (6毫克/公斤每8小时) 或安慰剂,连续24小时的门诊心电图 (ECG) 监测.
- 业主和临床医生进行了行为评估.
主要成果:
- 特拉佐的使用导致了显著更高的平均和最小HRs (分别P=0.035,P<0.001) 和降低的HRV参数 (P<0.001).
- 在trazodone和安慰剂组之间没有观察到来自ECG的QTi的显著差异.
- 根据主人和临床医生的评估,用特拉佐治疗的狗表现出更平静的行为 (P<0.001,P=0.006).
结论:
- 在健康的狗中,特拉佐会增加HR并降低HRV,这可能是由于抗胆固醇作用或血压介导的反射.
- 在这个研究群体中,标准的特拉佐剂量并没有对QTi产生显著影响.
- 需要进一步的研究来阐明精确的机制,并排除混因素,如血压和药物水平.
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