具有水键的超分子纳米海绵:用于pH触发药物输送的智能解决方案
Serap Sezen1, Atefeh Zarepour2, Ali Zarrabi3
1Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul 34956, Turkiye.
Colloids and surfaces. B, Biointerfaces
|July 4, 2025
概括
装有多克索鲁比 (Dox) 的新型响应pH的环氧德克斯特林纳米海绵 (CDNS) 增强了抗癌药物输送. 这些智能材料显示pH值依赖的Dox释放和改善细胞吸收,为癌症治疗提供了一个有希望的替代方案.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 制药科学 制药科学
背景情况:
- 循环德克斯特林纳米海绵 (CDNS) 是先进的药物输送系统.
- 现有系统经常面临药物疗效和副作用的挑战.
- 响应刺激的智能材料为有针对性的交付提供了潜在的解决方案.
研究的目的:
- 为增强抗癌药物输送开发新的pH响应性CDNS.
- 将多克索鲁比 (Dox) 装入这些纳米海绵中作为一种模型药物.
- 评估Dox装载NS的特性,药物释放和生物活性.
主要方法:
- 通过CD氧化和与基酸二化物交叉连接合成pH响应的CD NSs.
- 将多克索鲁比辛 (Dox) 装入合成的纳米海绵.
- 描述了纳米海绵的形态,热稳定性,结构,尺寸和表面电荷.
- 在不同的pH值 (7.4和5.5) 下评估的Dox释放.
- 在MCF-7和L929细胞系中评估了细胞毒性和细胞吸收.
主要成果:
- 成功合成了具有中性表面电荷的球形,热稳定,无形CD NSs.
- 实现了大约58%的DOX封装效率.
- 证明了pH依赖的Dox释放,pH为5.5的释放量是pH7.4的1.5倍,而pH为5.5的释放量是pH7.4的1.5倍.
- 与自由Dox (2.12μM) 相比,NS-Dox对MCF-7和L929细胞没有毒性,IC50 (0.82μM) 较低.
- 增强细胞对Dox的吸收 (69%的NS-Dox与38%的免费Dox在2小时后) 和类似的核定位.
- NS-Dox保护L929细胞免受Dox介导的毒性.
结论:
- 开发了一种新的,具有成本效益的,对pH值有反应的CDNS系统,用于药物输送.
- 响应pH的特性允许在酸性瘤微环境中有针对性的药物释放.
- 增强的Dox吸收和降低的毒性突出显示了这些NSs在改善癌症治疗方面的潜力.
- 这种响应pH的CD NS平台显示出作为针对药物输送应用的智能材料的前景.
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