益生菌增强骨密度和减少炎症 脊髓后手术
Dongjie Fu1, Xiaoxiang He2, Jian Lu3
1Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan, China.
International dental journal
|July 4, 2025
概括
通过补充Lactobacillus reuteri的益生菌,通过减少炎症和增加微生物多样性,在手术后增强了膜骨密度和稳定性. 需要进一步的研究来证实这些有希望的发现.
科学领域:
- 在口腔外科手术中.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 气膜骨恒温和炎症是口腔外科手术后的关键因素.
- 益生菌干预正在研究它们的治疗潜力.
研究的目的:
- 评估Lactobacillus reuteri益生菌在调节周围组织炎症方面的临床疗效.
- 评估益生菌对口腔外科手术后维持膜骨平衡的影响.
主要方法:
- 一个开放的标签试验,涉及80名接受大气管外科手术的患者.
- 随机分为一个益生菌组 (Lactobacillus reuteri DSM 17938) 和一个标准护理对照组.
- 评估骨密度 (CBCT),口腔微生物多样性 (16S rRNA) 和炎症标志物 (IL-1β,TNF-α,IL-6) 在指定间隔.
主要成果:
- 益生菌组的骨密度显著增加 (3.8%),微生物多样性增加 (15.2%).
- 在益生菌组中观察到关键炎症标志物 (IL-1β,TNF-α,IL-6) 的显著减少.
- 益生菌补充剂减轻了炎症,增强了膜骨的稳定性,这表明它对骨质整合具有潜在的临床意义.
结论:
- 乳杆菌reuteri益生菌有效调节炎症,并改善了手术后的膜骨平衡.
- 这些发现表明益生菌在骨再生策略中的潜在益处.
- 建议在未来对更大群体进行双盲试验,以验证这些结果.
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