定义骨折相关感染的治疗结果:一个范围审查
Noémie Reinert1, Laura Bessems2, Jolien Onsea2
1Center of Musculoskeletal Infections, Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Basel, Switzerland; University of Basel, Basel, Switzerland.
Injury
|July 4, 2025
概括
缺乏关于骨折相关感染 (FRI) 的标准化结果报告. 本次审查强调,迫切需要明确的定义,以提高FRI临床研究的可比性和透明度.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 临床研究方法论 临床研究方法论
背景情况:
- 2018年的骨折相关感染 (FRI) 共识定义改善了临床实践和研究的标准化.
- 然而,缺乏标准化结果参数会阻碍对治疗成功的准确评估,并可能导致对治疗失败的错误报告.
- 本范围审查审查审查了当前FRI文献中使用的结果参数.
研究的目的:
- 提供文献中用于评估骨折相关感染治疗成功或失败的结果参数的概述.
- 在最近的FRI研究中确定标准化结果报告的程度.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science进行了全面的文献搜索.
- 包括在2018年至2023年之间发表的关于成人长骨FRI治疗结果的研究.
- 评估的主要结局包括感染持久性/根除/复发,放射性和功能性结局,并返回剧院进行感染控制.
主要成果:
- 在111项包含的研究中,只有15.3%的研究明确定义了治疗成功/失败.
- 虽然在85.6%的病例中报告了感染根除,但准确的定义很少 (例如,持久性为0%).
- 经常报告骨愈合 (90.9%),但功能性结果缺乏标准化评分,并且没有确定标准的随访持续时间.
结论:
- 这一范围审查揭示了骨折相关感染研究中标准化结果报告的严重缺乏.
- 在FRI研究中迫切需要明确的定义和标准化的结果指标.
- 标准化对于提高临床研究的可比性和透明度以及改善患者护理至关重要.
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