影响性和非影响性精神病中的海马体积
Katie Gibbs1, Maureen McHugo2, Alexandra Moussa-Tooks3
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Schizophrenia research
|July 4, 2025
概括
情感精神病与后部海马体积的减少有关. 不完全的海马逆转 (IHI) 在精神病中更常见,可能表明风险增加.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 在非情感性精神病中的海马体积变化从前部向后部进展.
- 在情感精神病中,疾病进展对海马体积的影响仍然不清楚.
研究的目的:
- 在情感精神病中研究前后海马体积对前后海马体积的差异影响.
- 为了检查在情感精神病中不完全的海马体逆转 (IHI) 的流行率和影响.
主要方法:
- 分析了来自103个情感精神病,242个非情感精神病和214个健康对照组的结构性MRI数据.
- 使用自动细分来测量总体,前部和后部海马体积.
- 在所有组中评估了IHI的患病率和严重程度.
主要成果:
- 与健康对照人群相比,情感精神病患者的后部海马体积较小.
- 两组精神病患者之间没有发现总或区域海马体积的显著差异.
- 在非情感和情感精神病组中,IHI的患病率和严重程度都较高.
结论:
- 情感精神病与后部海马体积的减少有关,与前部区域不同.
- 不完整的海马逆转 (IHI) 可能作为精神病风险的生物标志物.
相关概念视频
Role of Hippocampus in Memory
561
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
561
Negative and Cognitive Symptoms of Schizophrenia
127
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
127
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
999
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
999
Positive Symptoms Schizophrenia: Hallucinations and Delusions
133
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
133
Schizophrenia
234
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
234


