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Updated: Sep 16, 2025

Laser-free Hydroxyl Radical Protein Footprinting to Perform Higher Order Structural Analysis of Proteins
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通过酶化水解和LC-MS/MS的使用,研究过氧化物诱导的Asp46在过氧化素2中的表皮化

Mohamed Abdulbagi1, Limin Wang1, Jiafeng Wang1

  • 1Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory on Protein Chemistry and Structural Biology, China Pharmaceutical University, Nanjing 210009, China.

Journal of pharmaceutical and biomedical analysis
|July 4, 2025
PubMed
概括

氨基酸立体反转,就像阿斯巴拉丁酸表皮化 (AAE) 一样,可以改变蛋白质功能. 这项研究在氧化应激后检测到D-Asp46在抗氧化酶Peroxiredoxin 2 (Prx2) 中,揭示了结合亲和力降低.

关键词:
(D) -Asp的使用情况.生物标志物生物标志物这是LC-MS/MS.氧化应激是一种氧化应激.类表皮质的表皮质.在prx2中使用Prx2

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