一项系统的文献综述和元分析评估了可修改的风险因素,用于发展BK多发性瘤病毒相关并发症
Michael Eder1, Alexander Kainz1, Haris Omic1
1Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Kidney international
|July 4, 2025
概括
结核多重瘤病毒相关性病 (BKPyVAN) 是造成移植损伤的主要原因. 这次元分析没有发现单一的风险因素,这表明对BKPyV复制的免疫控制不足是关键.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 病毒学 病毒学
背景情况:
- 结核多重瘤病毒相关性病 (BKPyVAN) 是移植损伤的重要原因之一.
- 现有的风险因素数据主要基于单一或回顾性研究.
- 需要进行系统性审查和元分析,以验证BKPyV.可修改的临床风险因素.
研究的目的:
- 进行系统的文献审查和元分析.
- 提供可靠的假设,并测试BKPyV.已知可修改的临床风险因素的可重复性.
- 在成年移植患者中分析BKPyV并发症.
主要方法:
- 搜索了控制试验的Medline,Embase和Cochrane注册表.
- 包括对患有BKPyV并发症的成年移植接受者的前性和后性研究.
- 提取并计算的风险比率,使用随机效应模型将风险聚合起来,并评估偏差.
主要成果:
- 分析了165项涉及197029名患者的研究,其中29项具有高偏差风险.
- 皮质类固醇与三个终点相关,塔克罗利斯和抗胆小板球蛋白与两个终点相关.
- 其他因素包括塔克罗利斯水平,ABO不兼容的移植,rituximab,mycophenolate mofetil,mTOR抑制剂和尿路支架.
结论:
- 对于所有BKPyV并发症,没有单个独立的风险因素被确定.
- 在移植患者中预测BKPyV相关的并发症是复杂的.
- 对BKPyV复制的免疫控制不足可能会导致并发症.
关键词:
这就是BK病毒.BKPyVANAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN BKPyVAN移植后的传染性并发症.腎臟移植 腎臟移植
相关概念视频
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
59
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
59
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
54
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
54
01:24Chronic Kidney Disease II: Clinical Manifestations
104
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
104
01:28Chronic Kidney Disease III: Interprofessional Care
82
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
82
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
111
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
111
01:05Single Nucleotide Polymorphisms-SNPs
15.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.9K