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Updated: Sep 16, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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托法西替尼 (tofacitinib) 通过抑制产生ILC和T细胞的IFNγ来改善坎皮洛巴克特诱导的肠道病理

Anna A Korchagina1, Sergey A Shein1, Wayne T Muraoka1

  • 1Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.

Mucosal immunology
|July 4, 2025
PubMed
概括

托法西替尼通过抑制免疫细胞信号来减少小鼠中Campylobacter jejuni感染的肠道炎症. 这种JAK/STAT抑制剂可以缓解结肠炎而不影响细菌生长,提供潜在的治疗见解.

关键词:
坎比洛巴克特 (Campylobacter jejuniuni) 是一个常见的菌类.感染性结肠炎是一种感染性结肠炎.天生的淋巴细胞是先天性淋巴细胞.这就是JAK/STAT.托法西提尼布 (tofacitinib) 是一种可靠的药物.

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