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光学连贯性断层扫描与年龄相关的变化与玻璃眼相关的参数:系统性审查

Rodrigo Vilares-Morgado¹, Kamiel Verbruggen², Ingeborg Stalmans³

¹Department of Ophthalmology, Unidade Local de Saúde São João, Porto, Portugal; Cardiovascular R&D Centre - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.

Survey of ophthalmology

|July 4, 2025

概括

健康的衰老会导致光学连贯断层扫描 (OCT) 眼病参数的逐渐下降. 这种与年龄相关的变化必须在使用OCT或OCT血管学诊断青光瘤进展时考虑.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
老年学是指老年学的学科.

背景情况:

光学连贯断层扫描 (OCT) 对于检测青光眼的进展至关重要.
青光眼的参数测量可能会受到正常的衰老过程的影响.
准确的青光眼诊断需要考虑与年龄相关的变化.

研究的目的:

在健康个体中总结了与年龄相关的OCT玻璃眼参数的变化.
为了解决海洋和海上国家/地区数据的解释,以评估青光眼的进展.

主要方法:

51项纵向研究的系统综述和元分析.
使用OCT和OCT血管学 (OCTA) 分析了视网膜神经纤维层 (RNFL) 厚度,状细胞综合体 (GCC) 和状细胞内部状层 (GCIPL) 厚度,布鲁赫膜开口-最小边缘宽度 (BMOMRW) 和血管密度 (VD) 的年龄相关变化.

主要成果:

RNFL的厚度每年减少 -0.47 ± 0.27 微米 (Spectralis® OCT), -0.44 ± 0.17 微米 (Cirrus® OCT) 和 -0.25 ± 0.21 微米 (Optovue® OCT).
GCIPL的厚度减少了每年 -0.24 ± 0.08μm (Cirrus® OCT),GCC的厚度减少了每年 -0.40 ± 0.26μm (Optovue® OCT),BMOMRW减少了每年 -1.61 ± 0.14μm (Spectralis® OCT).
在OCTA (Optovue® OCT) 上,静脉疾病的变化为-0.33 ± 0.50%/年.

结论:

健康的老龄化导致OCT评估的关键绿眼病参数的持续,渐进的下降.
这些与年龄相关的规范性变化必须考虑在临床评估中,以避免误解正常的衰老为青光眼的进展.
根据与年龄相关的变化进行调整,将提高OCT和OCTA在诊断真正的绿眼病进展方面的特异性.

关键词:

与年龄相关的变化眼光障碍眼光障碍眼光障碍眼光障碍青光眼的进展情况.其他国家和地区.其他国家,地区和地区-A.视网膜神经纤维层厚度视网膜神经纤维层厚度

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