伴随性疾病负担和免疫治疗在转移性细胞癌中的有效性
Emre Yekedüz1, Martin Zarba2, Eddy Saad3
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Türkiye.
Clinical genitourinary cancer
|July 4, 2025
概括
接受免疫检查点抑制剂 (ICI) 治疗的转移性细胞癌 (mRCC) 患者的高并发症负担与更糟糕的结局有关. 这凸显了在mRCC护理中需要全面的并发症评估的必要性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞癌研究 细胞癌研究
背景情况:
- 癌症患者的并发症使治疗和试验资格复杂化.
- 转移性细胞癌 (mRCC) 患者往往有同时存在的健康问题.
- 免疫检查点抑制剂 (ICI) 越来越多地用于mRCC,但伴随性疾病的影响需要澄清.
研究的目的:
- 评估第一线ICI治疗的mRCC患者的并发症负担和结果之间的关联.
- 评估并发症对治疗失败的时间 (TTF) 和整体存活率 (OS) 的影响.
- 为了确定伴随性疾病负担是否影响不良事件 (AE) 率导致治疗修改.
主要方法:
- 对304名第一线ICI治疗的mRCC患者的回顾性分析.
- 伴随性疾病负担使用年龄调整的查尔森伴随性疾病指数 (CCI) 来评估.
- 患者分为高CCI和低CCI组;TTF,OS和AE率进行了比较.
主要成果:
- 在mRCC患者中,较高的CCI得分与较差的TTF (HR 1.51) 和OS (HR 1.98) 有关.
- 导致剂量减少或中止的副作用的发生率在高CCI和低CCI组之间是相似的.
- 常见的并发症包括糖尿病,以前的心肌梗塞和慢性脏/肺部疾病.
结论:
- 相当大的并发症负担会对接受一线ICI治疗的mRCC患者的结果产生负面影响.
- 尽管AE概况相似,但高并发病率是较差生存率的预测因素.
- 对于管理ICI组合的mRCC患者而言,对并发症的多维评估至关重要.
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