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食品添加剂二氧化对免疫能力强的细胞进行向

John W Wills¹, Alicja Dabrowska², Jack Robertson²

¹Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. jw2020@cam.ac.uk.

Nature communications

|July 4, 2025

概括

食品级二氧化 (fgTiO2) 在肠道内的免疫细胞中积累,而不是静止细胞. 一种新的小鼠模型允许对这些生物持久纳米粒子进行与人类相关的风险评估.

科学领域:

免疫学免疫学免疫学
纳米毒理学研究
胃肠病学胃肠病学

背景情况:

食品级二氧化 (fgTiO2) 是一种生物持久纳米粒子,面临监管审查.
以前,人们认为fgTiO2只能在静止的肠道色素细胞中积累.

研究的目的:

在人类中识别fgTiO2的免疫能力细胞标.
开发一种小鼠模型,以评估摄入fgTiO2.2对人类的相关风险.

主要方法:

多模态显微镜与单粒子检测.
相对剂量测量用于量化细胞暴露.
对92个蛋白质标进行近距离扩展分析.
在fgTiO2养小鼠模型中,口服沙门氏菌的挑战.

主要成果:

微细胞将fgTiO2引导到皮耶斑块中的免疫能力强的LysoMac和LysoDC细胞中.
没有观察到单独fgTiO2对细胞信号通路的可测量的干扰.
沙门氏菌感染诱导了细胞迁移和促炎信号,但fgTiO2没有增强这种反应.

结论:

免疫能力的细胞,而不是静止的色素细胞,是fgTiO2.
一个小鼠模型成功地回顾了人类fgTiO2组织分布,并使风险评估成为可能.

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