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Updated: Aug 15, 2026

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

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接种了甲非活化SARS-CoV-2免疫的仓鼠在感染后会发展出加速的肺组织病理病变和Th2偏差反应

Rineke de Jong1, Sandra Vreman2, Katrin E Wiese2

  • 1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands. rineke.jong@wur.nl.

NPJ vaccines
|July 4, 2025
PubMed
概括

这项研究发现,在接种疫苗时,叙利亚仓鼠在感染SARS-CoV-2后没有表现出增强的疾病,这表明模型是这样的.

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...