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Updated: Sep 16, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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精确编辑的基因组尾巴扰乱了试管体中多基因基因表达控制的多基因表达控制

Markéta Novotná1, Michele Tinti1, Joana R C Faria2

  • 1School of Life Sciences, University of Dundee, Dundee, UK.

Nature communications
|July 4, 2025
PubMed
概括

希斯H4尾部的修饰调节了Trypanosoma brucei中的基因表达. 模仿 lysine 4 或 14 的乙化特征的特定突变减少了邻近基因的表达,显示出对多基斯特朗转录的直接控制.

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