阿斯巴甜和缺血性中风:通过网络毒理学和分子对接分析解开分子链接
Tianyu Zhang1, Tao Wang1, Kuangyang Yu1
1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Scientific reports
|July 4, 2025
概括
根据网络毒理学和分子对接,阿斯巴甜可能通过破坏炎症和血管通路来增加缺血性中风风险. 需要进一步的研究来证实这些神经毒性作用和剂量反应关系.
科学领域:
- 毒理学 毒理学 毒理学
- 计算生物学 计算生物学
- 神经科学是一个神经科学.
背景情况:
- 作为一种常见的人工甜味剂的阿斯巴甜,因其代谢产物的潜在神经毒性风险而面临审查.
- 流行病学研究表明,人工甜味剂和脑血管疾病之间存在联系,但分子机制仍然难以捉摸.
- 了解阿斯巴甜对缺血性中风的影响对于公共卫生和食品安全至关重要.
研究的目的:
- 研究阿斯巴甜对缺血性脑损伤的潜在贡献背后的分子机制.
- 通过使用综合网络毒理学和分子对接来确定阿斯巴甜所影响的关键分子标和途径.
- 为食品添加剂安全和中风预防提供对阿斯巴甜的神经毒性的系统洞察.
主要方法:
- 网络毒理学方法使用STITCH,SwissTargetPrediction和SEA数据库来预测阿斯巴甜的目标.
- 从GeneCards,OMIM和TTD数据库中识别与缺血性中风相关的基因.
- 维恩分析以确定重叠的基因,其次是GO/KEGG丰富分析和分子对接模拟.
主要成果:
- 在阿斯巴甜标和缺血性中风基因之间确定了201个重叠基因,IL1B,MMP9,SRC,AGT和TNF被突出显示为核心标.
- 丰富分析揭示了阿斯巴甜对氨酸- ангиотензин系统,补充/凝固级联和炎症通路的潜在调节.
- 分子对接证实了阿斯巴甜与主要识别的标之间强烈的结合亲缘关系,表明直接相互作用.
结论:
- 亚斯巴甜可能通过多目标相互作用导致缺血性脑损伤,可能影响炎症反应和血管平衡.
- 这项研究提供了对阿斯巴甜的神经毒性机制的初步系统洞察.
- 需要进一步验证以阐明代谢物协同作用和剂量反应关系,以进行全面的风险评估.
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