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在PRINCIPLE随机对照开放标签平台试验中,氧化用于治疗高风险社区患者的COVID19

F D Richard Hobbs¹, Jienchi Dorward², Gail Hayward²

¹Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. Richard.hobbs@phc.ox.ac.uk.

Scientific reports

|July 4, 2025

概括

在英国的一项试验中,氧化并没有减少怀疑COVID-19的住院或死亡. 该研究没有发现益处的证据,两组之间住院率相似.

科学领域:

临床医学临床医学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

早期的COVID-19大流行缺乏确定的诊断,导致对综合征性疾病的试验.
氧化对治疗COVID-19的潜在益处进行了调查.
高风险患者需要有效的社区治疗来预防住院治疗.

研究的目的:

评估氧化在预防高风险COVID-19患者入院的有效性.
评估氧化对疑似COVID-19病例死亡率的影响.
在PRINCIPLE试验的自适应平台中分析治疗结果.

主要方法:

一个全国性的,开放标签,随机临床试验 (原则) 在英国社区护理.
参与者 (≥65岁或≥50岁具有并发症) 随机选择了≤14天的症状.
干预:通常的护理加上氧化 (200毫克两次7天) 和单独的通常护理.

主要成果:

由于外部监管的决定,氧化基因手臂被提前停止.
住院或死亡发生在3.7% (化) 和3.1% (常规护理) (OR1.04 [95%BCI 0.36至3.00]) 的情况下.
医院住院或死亡没有显著差异;与氧化更频繁的恶心.

结论:

没有证据表明氧化可以减少COVID-19疑似患者的住院或死亡.
由于早期停止,试验组的功率不足,限制了最终的结论.
这些发现有助于了解COVID-19的早期流行病治疗策略.

关键词:

氧化chloroquine 的使用情况.初级医疗保健是主要的医疗保健.重新使用的药物.这就是SARS-COV-2病毒.严重的COVID严重的

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