双向门德尔随机化分析血清维生素D水平与多种脏疾病之间的因果关系

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ShuiFang Chen¹, Hui Chen², XueMei Chen³

¹Department of pharmacy, Xiamen Hospital, Beijing University of Chinese Medicine, Xiamen, 361009, Fujian, China.

Scientific reports

|July 4, 2025

概括

这项研究发现,维生素D水平与IgA脏病 (IgAN),膜性脏病 (MN) 或糖尿病脏病 (DN) 的风险之间没有因果关系. 这些发现表明,补充维生素D可能不是这些病的预防策略.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
内分泌学在内分泌学.
遗传学遗传学是一个

背景情况:

观察性研究表明,维生素D水平与病风险之间存在着争论的关系.
具体的脏疾病包括IgA脏病 (IgAN),膜性脏病 (MN) 和糖尿病脏病 (DN).

研究的目的:

评估维生素D与Igan,MN和DN之间的因果关系.
使用双向门德尔随机化 (MR) 方法来进行可靠的因果推理.

主要方法:

获得的全基因组关联研究 (GWAS) 总结水平数据是血清25(OH) D和三个脏疾病.
采用逆方差加权 (IVW) 方法作为主要的MR分析技术.
进行了灵敏度分析 (Cochran's Q,MR-Egger拦截,留出一个) 以确保结果的有效性和检测性.

主要成果:

在血清25(OH) D水平和Igan,MN或DN的风险之间没有确定统计学上显著的因果关系.
敏感性分析证实了零结果的稳定性和可靠性.
门德尔的随机化分析强烈驳斥了基因决定的维生素D水平与这些病之间的因果关系.

结论:

基因决定的维生素D水平不会对Igan,MN或DN的风险产生因果影响.
这些发现挑战了目前用于预防病的维生素D补充剂的模式.
临床医生应优先考虑针对可修改风险因素的干预措施,而不是对维生素D优化进行脏疾病的管理.

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