在患有慢性病第3期和第4期的患者中,甲状腺功能和蛋白尿之间的相关性
Karina Schiavoni Scandelai1, Pietra Desiree Bourdon Fuentes Azevedo Vianna2, João Pedro Barbosa Sanches2
1Postgraduate Program in Clinical and Experimental Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
International urology and nephrology
|July 4, 2025
概括
慢性病 (CKD) 3期和4期的蛋白尿与甲状腺功能改变有关,较高的蛋白质损失与甲状腺刺激激素 (TSH) 增加和自由T4 (FT4) 减少有关. 甲状腺功能在CKD阶段3和4之间没有显著差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 临床化学 临床化学
背景情况:
- 脏病综合征中的蛋白尿可能导致甲状腺激素失衡.
- 亚临床甲状腺功能低下症可能是由于甲状腺素结合蛋白和levothyroxine的损失引起的.
- 在慢性病 (CKD) 中了解甲状腺功能对于患者管理至关重要.
研究的目的:
- 为了研究甲状腺功能和蛋白尿之间的相关性,在3期和4期CKD的患者中.
- 为了确定甲状腺功能是否在CKD阶段3和4之间有所不同.
- 评估尿路蛋白质损失对甲状腺激素水平的影响.
主要方法:
- 进行了一项观察性,横截面研究,对150名被诊断为CKD第3期和第4期的患者进行了观察.
- 测量包括甲状腺刺激激素 (TSH),自由T4 (FT4) 和尿蛋白-肌素比率 (PCR).
- 蛋白尿症被定义为PCR≥200 mg/g.
主要成果:
- 在PCR和TSH之间观察到显著的正相关性,在总样本和CKD第3阶段PCR和FT4之间观察到负相关性.
- 超过60%的患者表现出蛋白尿 (PCR ≥200 mg/g).
- 在患有和没有显著蛋白尿的患者之间,发现了年龄,估计的球过率,TSH和FT4的显著差异.
结论:
- 尿路蛋白质损失与CKD第3期和第4期甲状腺功能变化有显著的相关性.
- 甲状腺功能参数 (TSH和FT4) 根据蛋白尿的存在显示出显著差异.
- 在CKD阶段3和4之间没有发现甲状腺功能的显著差异.
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