使用电子健康记录标记长期COVID的高效表型
Chuan Hong1, Jun Wen2, Harrison G Zhang2,3
1Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
NPJ digital medicine
|July 4, 2025
概括
一种名为LAbel-efficienT Long COVID pHenotyping (LATCH) 的新算法,可以使用电子健康记录来改善长期COVID病例的识别. 这种方法提高了长期COVID患者的风险预测和管理.
科学领域:
- 传染性疾病 传染性疾病
- 医疗信息学 医疗信息学
- 公共卫生 公共卫生
背景情况:
- 长期COVID由于其多样化的症状和不一致的编码, presents一个重要的全球健康挑战.
- 准确识别长期COVID病例对于风险预测和有效的患者管理至关重要.
- 目前仅依赖特定电子健康记录 (EHR) 代码的方法不足以进行全面的长期COVID表型化.
研究的目的:
- 使用EHR数据开发和验证长期COVID的高效表型算法.
- 为了提高长期COVID分类的准确性,超越现有的编码实践.
- 为了提高病例识别,利用标记和未标记的EHR数据.
主要方法:
- 介绍了LAbel-efficientT长期COVIDpH基因型定型 (LATCH) 算法.
- LATCH合成了一小组黄金标准标签与一个大型未标签的EHR数据集,其中包含众多功能.
- 对LATCH算法的性能进行内部和外部验证.
主要成果:
- 与仅使用U09.9长COVID EHR代码的方法相比,LATCH表现优异.
- 下游分析显示,长期COVID患者的医疗保健利用率增加,感染后四个月后达到顶峰.
- 该算法有效地利用标记和未标记的数据进行改进的分类.
结论:
- LATCH算法提供了一种更强大的方法来分类长期COVID病例.
- 增强分类为长期COVID相关的医疗保健利用模式提供了关键的见解.
- 这些发现可以为临床实践和公共卫生策略提供信息,以管理长期COVID的长期影响.
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