在中年和老年人群中,铁积累和肉症之间的相关性
Mahamane Rahoufou Tounaoua1,2, Honggu Chen2, Zakari Shaibu1
1Department of Orthopedics, the Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, China.
BMC musculoskeletal disorders
|July 4, 2025
概括
血清费里水平升高与老年人肉症风险增加有关. 一个U形的关系表明,低和高的铁储量可能会影响肌肉健康.
科学领域:
- 老年学是指老年学的学科.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 标志着与年龄相关的肌肉质量和力量丧失的萨尔科佩尼亚,在老年人中构成了重大健康挑战.
- 铁代谢在细胞功能中起着至关重要的作用,但其与肉症的特定关联仍然不完全理解.
研究的目的:
- 调查铁积累标志物与老年人群中 Sarcopenia 发展风险之间的关系.
- 探索血清费里水平与肉症风险之间的潜在非线性关联.
主要方法:
- 进行了一项涉及110名老年参与者的横截面研究 (44名男性,66名女性).
- 收集的数据包括人口统计,身体组成,炎症标志物和铁状况指标 (血清铁,费里丁,TIBC,TSAT).
- 统计分析采用t测试,奇方测试,二进制逻辑回归和通用添加模型 (GAMs) 来进行非线性分析.
主要成果:
- 血清费里水平被确定为肉类的重要危险因素 (OR=1.005,P=0.042).
- 在血清费里和肉类症风险之间观察到具有统计学意义的U形关系.
- 肉类的风险降低到~226.4μg/L的费里,而在~241.2μg/L以上则增加.
结论:
- 在健康的老年人中,血清费里丁可以作为类病的独立风险因素.
- 这种非线性,U形的关联凸显了铁含量与肌肉健康之间的复杂相互作用.
- 需要进一步的研究,以澄清铁代谢在肌肉衰老中的作用,并为预防肉类症提供有针对性的干预措施.
更多相关视频
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
676
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.7K
相关概念视频
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:09Changes in the Appendicular Skeleton with Age
2.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.3K
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
01:26Aging
191
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
191