狄氏氨酸可以通过激活肉的AhR通路来增强托芬代谢和肠道免疫功能
Yue Su1,2, Miaomiao Wang1,2, Zhiyong Wu1,2
1College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Journal of animal science and biotechnology
|July 4, 2025
概括
血氨酸 (SAN) 在 brojlers 中转化为二氨酸 (DHSA),增强肠道免疫力和生长. DHSA增强乳酸菌,通过AhR通路调节酸盐代谢,改善肠道健康.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 营养生物化学 营养生物化学
背景情况:
- 氨酸对宿主健康至关重要,但内源合成是不可能的.
- 肠道微生物群和天然产品可以影响托代谢和宿主免疫力.
- 血红素 (SAN) 显示出增强 brojler 免疫力的潜力,但其生物可用性和机制尚不清楚.
研究的目的:
- 阐明血红素增强肉肠道免疫功能的机制.
- 为了确定肉肠中的血液代谢物,并评估它们对免疫功能和生长的影响.
主要方法:
- 液体染色学-并联质谱学 (LC-MS/MS) 确定了血液中的代谢物.
- 肉的饮食补充了血红素 (SAN) 和其主要代谢物二血红素 (DHSA).
- 用16S rRNA基因测序,托代谢和基因表达分析来评估肠道免疫功能.
主要成果:
- 确定了二松氨酸 (DHSA) 是SAN的主要肠道代谢产物.
- SAN和DHSA都改善了生长性能,增强了肠道形态 (维卢斯高度,V / C比率),并上调了紧结蛋白.
- SAN和DHSA促进了乳酸菌的扩散,增加了短链脂肪酸,通过酸碳水化合物受体 (AhR) 途径调节了酸代谢,并改变了细胞因子配置,使其达到抗炎状态.
结论:
- 血氨酸在体内转化为DHSA,增加其生物可用性和疗效.
- 通过调节肠道微生物群,DHSA增强肉肠道免疫力和生长,特别是增加乳酸菌的丰度.
- DHSA激活了基碳化合物受体 (AhR) 途径,调节了酸盐代谢和免疫反应,从而改善了宿主健康.
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