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在侵蚀性和网状口腔平坦液中对瘤突变负担的比较分析

Priscila Laiza Rubim Leão¹, Rennan Garcias Moreira², Fernanda Faria Rocha¹

¹Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

|July 5, 2025

概括

瘤突变负担 (TMB) 分析显示,侵蚀性和网状口腔平坦 (OLP) 亚型之间没有显著差异. 这些发现表明,OLP两种形式的基因突变模式都类似,需要进一步进行分子研究.

科学领域:

口腔病理学口腔病理学
在瘤学瘤学.
遗传学遗传学是一个

背景情况:

口腔平坦 (OLP) 是一种慢性炎症状况.
侵蚀性和网状OLP都被认为是潜在的恶性口腔病变.
恶性转变的潜力在OLP亚型之间有所不同,并未得到充分证实.

研究的目的:

为了比较侵蚀性和网状OLP中的瘤突变负担 (TMB).
为了研究OLP亚型的体质突变.

主要方法:

使用了下一代测序.
使用了QIAseq定向DNA人类TMB面板.
分析了18名OLP患者 (9名侵蚀性,9名网状) 的样本.

主要成果:

在侵蚀性和网状OLP之间没有观察到TMB的显著差异.
大多数样本具有低TMB (≤10突变/Mb) 或零TMB.
鉴定的突变涉及免疫反应和瘤抑制基因.

结论:

在侵蚀性和网状OLP中,遗传突变事件看起来相似.
需要进一步的分子研究来证实这些发现.
这项研究有助于了解OLP的恶性潜力.

关键词:

恶性转变的恶性转变在口腔中,有平坦的海.瘤突变的负担是巨大的

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