调节食道微生物组可能是治疗埃索诺菲尔食道炎的答案吗?
Sonia Facchin1,2, Erica Bonazzi1, Antonietta Tomasulo3
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Expert review of gastroenterology & hepatology
|July 5, 2025
概括
异性食道炎 (EOE) 管理越来越多地与口腔和食道微生物群有关. 益生菌治疗显示出作为补充疗法的承诺,以改善EoE结果.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 口腔和食道微生物群在性食道炎 (EoE) 中起着至关重要的作用.
- 食道屏障的功能障碍,与微生物群相关,导致EoE症状,如消化不良和胸痛.
- 对EoE的药理治疗和饮食干预可以改变食道和肠道微生物群的组成.
研究的目的:
- 探索口腔和食道微生物群在治疗异性食道炎 (EoE) 中的作用.
- 调查益生菌治疗作为EoE辅助疗法的潜力.
- 从2013年到2025年,审查文献,将EoE与微生物组和微生物群研究联系起来.
主要方法:
- 对EoE和微生物组-微生物群相互作用的出版物的文献综述.
- 分析传统EoE治疗对肠道和食道微生物群的影响.
- 综合关于益生菌在EoE中的应用的新兴研究.
主要成果:
- 食道微生物群被认为是EoE病原和管理的重要因素.
- 传统的EoE治疗可以影响食道和肠道微生物群的组成.
- 益生菌干预正在成为EoE潜在的补充治疗策略.
结论:
- 口腔和食道微生物群作为诊断生物标志物和EoE的治疗点是有价值的.
- 益生菌提供了一个有前途的途径,以提高EoE治疗疗效和患者遵守.
- 对益生菌的进一步研究可能会导致减少副作用和改善EoE管理中的缓解率.
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