用专利蓝色V的口腔微囊染色学可安全有效地改善腺瘤检测
Berenice Schulte1, Georg H Waetzig2,3, Johannes Bethge1
1Interdisciplinary Endoscopy, Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
使用专利蓝色V (PBM) 微囊的新型口服输送系统在结肠镜检查期间改善了聚的检测. 这种安全有效的方法增强了粘膜可视化,可以更好地检测多和腺瘤.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 药物输送系统 药物输送系统
背景情况:
- 染色体镜提高了聚/腺瘤检测率 (PDR/ADR).
- 目前用于染色体镜的方法是繁的.
- 口服输送系统为改善临床整合提供了潜在的解决方案.
研究的目的:
- 开发一种口服,营养级的输送系统,用于结肠粘膜染色.
- 评估该系统对结肠释放,粘膜染色和PDR/ADR的疗效.
- 为了建立一个口腔染色内学模式的概念验证.
主要方法:
- 使用的食品级贝微囊释放专利蓝色V (PBM) 根据pH和时间.
- 在肠道准备过程中口服给35名接受结肠镜检查的志愿者6粒囊.
- 使用五分尺度评估粘膜染色,并将PDR/ADR与倾向性得分匹配的队列进行比较.
主要成果:
- 97.1%的参与者实现了最佳至可接受的粘膜染色.
- 与对照组相比,PBM组的息肉检测率 (PDR) 在PBM组 (62.8%) 显着更高 (42.9%;p=0.04).
- 在PBM组中,每次结肠镜检测出显著增加的息肉和腺瘤数量.
结论:
- 这种新的PBM口服输送系统在染色体镜检测中证明了粘膜的均染色.
- 延迟释放PBM是一种安全有效的替代传统染料喷涂技术.
- 这种方法为现有的口腔染色内镜方式提供了可行的选择.
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