三重阴性乳腺癌中的雄激素受体表达:来自第三级护理中心的报告
Atika Dogra1, Vidya Krishna1, Dinesh Chandra Doval2
1Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
Journal of cancer research and therapeutics
|July 5, 2025
概括
在三阴性乳腺癌 (TNBC) 中,雄激素受体 (AR) 表达与明显的临床特征和较差的生存结果有关. 与四重阴性乳腺癌 (QNBC) 相比,AR阳性TNBC患者的无病和整体存活时间较短.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 由于研究结果相互矛盾,雄激素受体 (AR) 在三阴性乳腺癌 (TNBC) 的预后意义仍然不清楚.
- 研究AR表达可以完善TNBC亚型的预后标志物.
研究的目的:
- 为了比较AR阳性TNBC和四重阴性乳腺癌 (QNBC) 之间的临床病理学特征和生存率.
主要方法:
- 利用来自281名患者的组织微阵列 (TMA) 来进行AR表达的免疫组织化学分析.
- 定义的AR阳性为至少1%的核染色.
- 从电子医疗记录中收集和统计分析临床病理和生存数据.
主要成果:
- 在52例TNBC中检测到AR表达 (约18.5%).
- AR阳性与诊断时的年龄较大,瘤尺寸较小,瘤等级较低,非基底类型的表型以及远程复发风险增加相关.
- 对AR阳性TNBC的10年无病生存率为73%,对QNBC的78%.
- 对AR阳性TNBC的10年总生存率为72%,对QNBC的75%.
结论:
- 雄激素受体在三阴性乳腺癌的显著子集中得到表达.
- 在TNBC中AR表达与有利的临床病理特征有关,但矛盾的是,与更差的生存结果有关.
- 四重阴性乳腺癌 (QNBC) 与AR阳性TNBC相比,显示出更高的生存率.
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