评估自动机器学习增强计划系统的有效性,并与手动计划系统进行比较分析
Anand Jadhav1, Ajinkya Gupte, Sachin Rasal
1Department of Radiation Oncology Sir H.N Reliance Foundation and Research Centre, Prarthana Samaj, Girgaon, Mumbai, Maharashtra, India.
Journal of cancer research and therapeutics
|July 5, 2025
概括
使用Varian Ethos智能优化引擎 (IOE) 进行前列腺癌自动辐射治疗规划,产生了与手动Eclipse治疗规划系统 (TPS) 相似的结果. 这种自动化方法显示了减少规划时间和资源的潜力,同时保持高质量的计划.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 癌症治疗技术 癌症治疗技术
背景情况:
- 放射治疗的目的是精确地向瘤输送辐射,将风险器官 (OAR) 的剂量降至最低.
- 手动处理计划是耗时且变化的;自动化计划旨在提高效率和一致性.
- 瓦里安的Ethos平台与智能优化引擎 (IOE) 提供自动化放射治疗规划.
研究的目的:
- 评估使用Varian Ethos IOE用于前列腺癌的自动化计划生成的有效性.
- 将自动化的Ethos计划与手动生成的Eclipse治疗计划系统 (TPS) 计划进行比较.
- 根据剂量限制,目标覆盖率,OAR节省和合规性来评估计划质量.
主要方法:
- 分析了15个前列腺癌患者的回顾性计划.
- 在Ethos TPS上重新计算和重新优化了Eclipse计划,生成了多个IMRT和VMAT计划.
- 比较的重点是满足预先规定的剂量约束和评估剂量参数.
主要成果:
- 在满足Ethos和Eclipse计划之间预先规定的剂量限制方面没有发现统计学上显著的差异.
- 这两种系统都实现了优异的PTV覆盖率 (V95>95%) 和最小的热点 (V105 <5%).
- 对两个计划系统来说,OAR节约和剂量一致性/均性是可比的,并且在可接受的临床限制内.
结论:
- 带有IOE的Ethos TPS可以生成与Eclipse TPS相比较的高质量的前列腺癌放射治疗计划.
- 自动化规划显示出减少规划时间和资源利用的潜力.
- 这些发现支持自动化放射治疗计划系统的临床实施.
相关概念视频
Manipulation and Analysis
61
GIS manipulation and analysis functions are vital for decision-making and planning. These activities range from data retrieval tasks, such as selecting information based on specific criteria, to advanced analytical techniques that address complex spatial problems.One critical GIS analysis method is overlaying, which combines multiple data layers to examine impacts. For example, overlaying a river-dammed lake boundary with road networks can identify affected infrastructure. Another common...
61
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
103
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
103


