一个关于肥胖历史发展的假设,它不仅仅是关于食物
1Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 26, 1958, Frederiksberg C, Denmark. fma@nexs.ku.dk.
Current obesity reports
|July 5, 2025
概括
肥胖病原包括超出当前食物环境的复杂因素. 一个新的假设整合了能量平衡和碳水化合物-胰岛素模型,表明长期的代谢转变导致体重增加和肥胖率增加.
科学领域:
- 生理学 生理学 生理学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 目前的肥胖模型,能量平衡模型 (EBM) 和碳水化合物胰岛素模型 (CIM),为体重增加提供了相互竞争的解释.
- 根据EBM,增加的能量摄入量先于脂肪,而CIM则表明增加的脂肪先于增加的进食.
- 关于过去50年来能源摄入量和肥胖率的流行病学数据存在争议.
研究的目的:
- 提出一种关于肥胖病原的新假设.
- 整合EBM和CIM的关键元素.
- 提出一个框架,追踪现代食品环境之外的肥胖的根本原因.
主要方法:
- 对能源摄入量和肥胖患病率的流行病学观察结果的审查.
- 对代谢率,食物摄入量,体力活动和脂肪的历史趋势 (100年) 的分析.
- 合并现有模型和历史数据的假设框架.
主要成果:
- 提出了一个结合EBM和CIM元素的假设.
- 该框架表明,肥胖的根本原因早于现代的食品环境.
- 长期趋势显示,在过去的一个世纪里,体重稳步增加,而休息代谢率下降.
- 20世纪70年代后肥胖率的加快与代谢率的降低,饮食摄入量和身体活动的变化有关.
- 肥胖是多因素的,涉及几十年的代谢途径的改变,促进脂肪沉积.
结论:
- 肥胖是一种复杂的,多因素疾病,有着深厚的历史根源.
- 受食物和非食物因素影响的新陈代谢途径的改变,有助于净脂肪沉积.
- 需要一个统一的框架来了解肥胖症的长期发展和日益增长的患病率.
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