从殖民者到罪祸首:从外科术后的内膜炎中对S. epidermidis的基因组和临床见解
Susanna Sagerfors1, Leandro Andrés Escobar-Herrera2,3, Thor Bech Johannesen2,3
1Department of Ophthalmology, Faculty of Medicine and Health, Örebro University, Örebro, 701 82, SE, Sweden. susanna.sagerfors@regionorebrolan.se.
概括
在瑞典,导致手术后内炎的葡萄球球菌 (Staphylococcus epidermidis) 可能源自患者自身的皮肤菌群,而不是医疗环境. 后部细分手术与这些感染中更快的症状发作和较低的甲基西林耐药性相关.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
- 微生物学 微生物学
背景情况:
- 外源性内眼膜炎是一种严重的眼内感染,通常是在眼部手术后发生的.
- 斯塔菲洛科克斯 (Staphylococcus epidermidis) 是与医疗相关的感染的常见原因,包括内.
- 了解S. epidermidis在内炎中的来源和基因组特征对于有效的预防和治疗至关重要.
研究的目的:
- 描述由Staphylococcus epidermidis引起的外源性内炎的临床表现.
- 为了研究S. epidermidis从内膜炎病例中分离出来的基因组特征.
- 为了将这些分离物与来自携带者和假肢关节感染的S. epidermidis进行比较.
主要方法:
- 基因组测序S. epidermidis从33例内甲虫病例中分离出来.
- 从患者医疗记录中追溯收集临床数据.
- 用S. epidermidis从健康个体的鼻子 (n=151) 和假肢关节感染 (n=138) 中分离的比较基因组分析.
主要成果:
- 后部部位手术,特别是视内注射,是最常见的前置手术 (76%).
- 经过后部细分手术的患者与前部细分手术病例相比,症状出现的时间更短 (中位数为3天) 和甲基西林耐药性更低.
- 在基因组上,Endophthalmitis S. epidermidis的分离物与健康个体的共生菌群更相似,而不是与医疗保健相关的菌株或来自假肢关节感染的菌株.
结论:
- 基因组分析表明,术后内炎中的S. epidermidis起源于患者的内生植物群.
- 医疗保健设施不太可能是这些特定S. epidermidis内甲虫感染的来源.
- 眼科手术的类型会影响症状发作和S. epidermidis endophthalmitis中甲素耐药性的流行.
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