在海湾战争退伍军人中的动脉样硬化心血管疾病与部署暴露的关系
Sarah T Ahmed1,2, Ruosha Li3, Lea Steele4
1Center Health Services Research & Development Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, TX, USA. sa6@bcm.edu.
Cardiovascular toxicology
|July 5, 2025
概括
墨西哥湾战争的退伍军人暴露在油井火灾烟雾,化学/生物剂和胺丸中,面临着动脉硬化心血管疾病 (ASCVD) 的更高风险. 这些暴露可能是该人群中ASCVD的显著风险增强剂.
科学领域:
- 环境健康 环境健康
- 心血管疾病流行病学
- 军事医学 军事医学
背景情况:
- 海湾战争退伍军人 (GWVs) 经历了多种有毒物质的暴露,包括油井火灾烟雾,化学/生物制剂和化 (PB) 药片.
- 烟雾和其他有毒物质的成分与动脉样硬化心血管疾病 (ASCVD),自主功能障碍和脂质异常的风险增加有关.
研究的目的:
- 评估1990-1991年海湾战争期间部署暴露与ASCVD临床风险因素之间的关联.
- 确定特定的环境危害与GWV中ASCVD发病率之间的关系.
主要方法:
- 利用了来自海湾战争时代队列和生物存储库研究 (n=942) 的数据.
- 采用多变量逻辑回归来评估部署暴露时间 (1-6天,7-30天,31+天) 和ASCVD之间的关联.
- 根据关键临床风险因素进行调整,包括高血压,糖尿病和高胆固醇.
主要成果:
- 暴露于油井火灾烟雾,PB药片和化学/生物剂7-30天与ASCVD有显著的关联.
- 长达7-30天的化学/生物剂暴露与高血压相关,而31天以上的暴露与ASCVD有关.
- 在对临床风险因素进行调整后,油井火灾烟雾,化学/生物剂和ASCVD之间的关联仍然显著.
结论:
- 对油井火灾烟雾,化学/生物剂和PB药物的部署暴露与GWV中ASCVD风险增加有关.
- 这些环境暴露可能会作为ASCVD的特定人群风险增强剂.
- 建议在GWV的个性化临床风险评估中考虑这些特定暴露.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
79
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
79
Peripheral Artery Disease I: Introduction
35
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
35
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
41
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
41
Atherosclerosis I: Introduction
92
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
92
Exercise and Cardiovascular Response
1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K
Peripheral Artery Disease III: Interprofessional Care
32
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
32


