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移植后的身体功能和生活质量的变化发生在接受两次全基血型造血干细胞移植的患者身上
Takahiro Takekiyo1, Yoshikiyo Ito2, Takayoshi Miyazono2
1Department of Rehabilitation, Imamura General Hospital, 11-23 Kamoikeshinmachi, Kagoshima, 890-0064, Japan. soutakekiyo@yahoo.co.jp.
International journal of hematology
|July 5, 2025
概括
第二次造血干细胞移植 (HSCT-2) 导致身体功能和生活质量 (QOL) 的下降比第一次移植 (HSCT-1) 更大. 保持体力活动至关重要,特别是在HSCT-2期间.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 康复科学 康复科学 康复科学
背景情况:
- 全基性造血干细胞移植 (HSCT) 是血液恶性瘤的关键治疗方法.
- 在最初的HSCT (HSCT-1) 后复发后,患者可能会接受第二次HSCT (HSCT-2).
- 重复HSCT对身体功能和生活质量 (QOL) 的影响需要进一步研究.
研究的目的:
- 为了比较第一个 (HSCT-1) 和第二个 (HSCT-2) 全基性HSCT之间的身体功能和QOL的变化.
- 在移植后识别肌肉强度和运动耐受性的特定缺陷.
- 评估HSCT对患者报告的QOL的影响.
主要方法:
- 对接受HSCT-1和HSCT-2治疗的17名患者的回顾性分析.
- 物理治疗评估包括手握强度 (肌肉强度) 和6分钟步行测试 (6MWT;运动耐受性).
- 使用医疗结果研究的36项简短形式健康调查 (SF-36) 来评估生活质量.
主要成果:
- 在HSCT-2 (-18.3%) 和HSCT-1 (-9.3%) 相比,在HSCT-2 (-18.3%) 后观察到手握强度的显著下降.
- 通过6MWT测量运动耐受性,在HSCT-2 (-12.6%) 和HSCT-1 (-5.1%) 后也显示出更明显的下降.
- SF-36得分表明,在HSCT-2 (-23.4分) 后,QOL的减少明显大于HSCT-1 (-4.3分) 后.
结论:
- 与第一个相比,在第二次HSCT期间,身体功能和QOL的下降显著地更明显.
- 这些发现强调了针对性干预的必要性,以保持重复HSCT患者的身体功能.
- 优先考虑维持体力活动的策略对于改善HSCT接受者的结果和QOL至关重要,特别是那些需要第二次移植的人.
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