增强的视觉错觉在帕金森病与心血管自主性衰竭的帕金森病
Tadashi Umehara1,2, Masahiro Mimori3, Tatsushi Kokubu4
1Department of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan. tumety@jikei.ac.jp.
概括
心血管自主功能障碍,包括神经性正静性低血压和卧卧式高血压,与帕金森病患者的轻微幻觉 (pareidolia) 有关. 这表明自主系统变化与早期PD视觉障碍之间存在联系.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
背景情况:
- 帕金森病 (PD) 是一种影响运动功能的神经退行性疾病.
- 心血管自主性衰竭是PD中常见的一种非运动性症状.
- 在PD中,自主功能障碍与轻微幻觉 (pareidolia) 之间的关系尚不清楚.
研究的目的:
- 为了研究心血管自主性衰竭和PD患者在没有结构良好的视觉幻觉中的帕雷多利亚之间的关联.
- 澄清自主功能障碍在早期PD中轻微视觉障碍的发展中的作用.
主要方法:
- 招募了133名没有结构良好的视觉幻觉的PD患者.
- 视觉幻觉反应是使用噪音对声学测试来评估的.
- 评估了心脏I-metaiodobenzylguanidine (I-MIBG) 的摄入量,神经性正静性低血压 (nOH) 和卧底高血压 (nSH).
主要成果:
- 38%的患者经历了pareidolia. 38%的患者经历了pareidolia.
- 帕雷多利亚独立地与nOH,认知障碍和症状持续时间较长有关.
- 帕雷多利亚的发病率增加也与nSH有关,但不是心脏的I-MIBG摄取.
结论:
- 神经性正静性低血压和卧卧式高血压与PD早期的pareidolia的严重程度有关.
- 需要进一步的研究来确定中心病理变化或交感神经系统退化是否是这种关联的基础.
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