在巴西四个大型血液中心与艾滋病毒感染相关的危险因素:一个多中心病例控制研究 (2009-2017)
Fernanda Dominique de Souza Gonçalves1, Flávia da Costa Silva1, Isabel Cristina Gomes Moura2
1Faculdade Ciências Médicas de Minas Gerais (FCM-MG), Belo Horizonte, MG, Brazil.
Hematology, transfusion and cell therapy
|July 5, 2025
概括
巴西的献血者查需要改进,因为人类免疫缺陷病毒 (HIV) 感染的关键风险因素被忽略了. 识别这些风险行为对于减少输血传播的艾滋病毒至关重要.
科学领域:
- 输血医学 输血医学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 输血传染性感染是一个不断变化的挑战.
- 与其他国家相比,巴西的人类免疫缺陷病毒 (HIV) 残留风险更高.
- 对捐赠者风险行为的持续监测对于捐赠前查至关重要.
研究的目的:
- 评估巴西献血者中与艾滋病毒感染相关的风险因素.
- 为了确定与献血者HIV阳性相关的人口和行为特征.
主要方法:
- 分析来自巴西四个主要血液中心 (2009-2017) 的献血者数据.
- 利用二进制物流回归模型来评估艾滋病毒感染的风险因素.
- 采用了使用R软件进行最终模型选择的逆向淘汰策略.
主要成果:
- 男性性别,不完整的中学教育,分居/离婚/寡妇身份以及同性恋/双性恋倾向是显著的人口风险因素.
- 工作场所暴露,静脉注射药物使用和与男性发生性关系的男性 (MSM) 是强烈相关的行为风险因素.
- 在研究的供体群体中确定了HIV感染的特定人口和行为相关性.
结论:
- 巴西目前的献血者查过程可能无法有效识别艾滋病毒感染高风险的个体.
- 建议进行进一步的研究,以加强查方案,降低艾滋病毒传播风险.
- 这些发现强调需要改进策略,以减轻输血中艾滋病毒残留风险.
关键词:
艾滋病毒风险因素 献血者 献血者更多相关视频
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