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一个新的可计算的表型来识别儿童的肺栓塞DrEn: The CENTIPEDE研究
Hilary Whitworth1, Kristina Wagner2, Allison Zelinski3
1Division of Hematology, Children's Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA; Clinical Futures, Children's Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.
Thrombosis research
|July 5, 2025
概括
这项研究开发了一种可计算的表型 (CP),用于在PEDSnet系统中识别儿科肺栓塞 (PE). 该CP表现出高准确度,有助于儿童罕见疾病研究.
科学领域:
- 儿科健康研究 儿科健康研究
- 医疗信息学 医疗信息学
- 罕见疾病流行病学 罕见疾病流行病学
背景情况:
- 儿科肺栓塞 (PE) 是一种罕见的疾病,需要多中心合作进行强有力的研究.
- PEDSnet是一个拥有10个儿科机构的学习健康系统,为研究罕见儿科疾病提供了一个平台.
研究的目的:
- 在PEDSnet数据中开发和验证可计算的表型 (CP) 以准确识别儿科PE.
主要方法:
- 在PEDSnet.net中使用费城儿童医院的数据开发和改进了一种算法.
- 对CP进行了验证,对盲目手动图表审查进行了验证,以确定准确性.
- 确定了PE患者的结果被评估,以评估PEDSnet对结果分析的能力.
主要成果:
- 优化的CP确定了152例儿科PE病例,使用的标准包括抗凝剂使用,PE诊断代码和成像研究.
- 性能指标包括96%的灵敏度,88%的特异性,90%的正预测值和95%的负预测值.
- 最初的结果验证表明,在识别输血和血栓溶解方面需要改进.
结论:
- 这项工作介绍了第一个儿科PE可计算的表型.
- 未来的研究将专注于多中心验证CP,并加强干预措施和结果的识别.
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