伊朗人口中因子V和XIII异常的基因型模式:元分析
Sadegh Abbasian1, Mojtaba Pouresmaeili Ravari2, Ali Sahebi3
1Department of Laboratory Science, Ilam University of Medical Sciences, Ilam, Iran.
概括
这项研究调查了伊朗的因子V (FV) 和因子XIII (FXIII) 基因突变. 在中风患者中,FV中的c.1691 G>A突变是常见的,而FXIII中的34Val/Leu突变与反复流产有关.
科学领域:
- 遗传学 是一个遗传学.
- 血液学 血液学 血液学
- 医学研究 医学研究
背景情况:
- 静血性疾病对患病率和死亡率有很大影响.
- 凝血异常的检查对于预防和治疗至关重要.
- 了解V因子 (FV) 和XIII因子 (FXIII) 的遗传模式至关重要.
研究的目的:
- 确定伊朗人口中V因子和XIII因子异常的基因型模式.
- 为了确定与血栓状况和不良结果相关的流行突变.
主要方法:
- 通过使用电子数据库 (Web of Science,PubMed,Scopus等) 的数据进行了元分析. 从1990年到2019年的时间.
- 根据PRISMA原则,包括了各种设计的研究,没有性别或语言限制.
- 在选了10,449项研究项目后,最终包括了11项研究.
主要成果:
- 突变c.1691 G>A (FV) 在FV缺陷患者中出现率最高.
- 在FXIII缺乏症中,34Val/Leu突变 (FXIII) 是最常见的.
- 在中风患者中,FV缺乏 (c.1691 G>A) 是普遍存在的;FXIII缺乏 (34Val/Leu) 与反复流产有关.
结论:
- 特定因子V和因子XIII基因突变与血栓状况的风险增加有关.
- 识别这些遗传倾向可以帮助管理中风和反复流产的风险.
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