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倾向于聚合的粉样β符合体的形态抑制剂:一个计算探索

Stefano Bosio1, Federico Falchi1, Chiara Rauzi2

  • 1Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy; Computational and Chemical Biology, Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy.

Computers in biology and medicine
|July 5, 2025
PubMed
概括

这项研究使用计算方法寻找可能阻止粉样β自我组装的分子,这是阿尔茨海默病的关键过程. 这些已识别的分子可能会减少有毒蛋白质聚合物的形成.

关键词:
聚合抑制剂 聚合抑制剂阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.粉样蛋白-β 是一种粉样蛋白-β聚合物的聚合.本质上是无序的蛋白质.分子动力学分子动力学

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