Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cross-reactivity00:42

Cross-reactivity

31.5K
Overview
31.5K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

813
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
813
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

931
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
931

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mapping SARS-CoV-2 immunity after an XBB.1.5 booster by antigenic cartography of merged human and hamster sera.

NPJ vaccines·2026
Same author

Antigenic characterization of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models.

bioRxiv : the preprint server for biology·2026
Same author

Predicting the antigenic evolution of seasonal influenza viruses using phylogenetic convergence.

bioRxiv : the preprint server for biology·2026
Same author

Protein Priming Followed by a Replication-Competent VSV-GP Vector Boost Induces Sustained Immune Control in Therapeutic Hepatitis B Vaccination.

Vaccines·2026
Same author

Near real-time data on the human neutralizing antibody landscape to influenza virus as of early 2026 to inform vaccine-strain selection.

bioRxiv : the preprint server for biology·2026
Same author

Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir.

Npj viruses·2026

相关实验视频

Updated: Sep 16, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.4K

暴露于两种抗原上不同的SARS-CoV-2变体会扩大中和模式.

Melanie M Schmitt1, Annika Rössler2, Antonia Netzl3

  • 1Institute of Virology, Department of Hygiene, Microbiology and Virology, Medical University of Innsbruck, Peter-Mayr-Str. 4b, 6020 Innsbruck, Austria.

Vaccine
|July 5, 2025
PubMed
概括

连续严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 暴露会增强现有的免疫力并扩大抗体反应. 然而,随后的变种暴露主要增强交叉反应性,而不是诱导新的变种特异性抗体.

关键词:
交叉中和是可以实现的.免疫印记 免疫印记是一种免疫印记.中和抗体的抗体.这就是SARS-CoV-2病毒.

更多相关视频

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

7.8K
Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K

相关实验视频

Last Updated: Sep 16, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.4K
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

7.8K
Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学
  • 传染性疾病 传染性疾病

背景情况:

  • 之前暴露于严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 变种,塑造了随后的中和抗体反应.
  • 连续暴露往往会加强先前存在的免疫力,并扩大交叉中和抗体,具有有限的诱导 de novo 变种特异性反应.

研究的目的:

  • 在正确两次暴露后,分析针对各种SARS-CoV-2变体的中和抗体反应.
  • 调查抗原特异变体暴露对中和幅度和特异性的影响.
  • 探索在SARS-CoV-2感染和疫苗接种中免疫印记的现象.

主要方法:

  • 对血样本中的中和抗体的分析来自具有定义双重暴露史的个体 (奥米克龙前/奥米克龙前,奥米克龙前/奥米克龙,奥米克龙/奥米克龙).
  • 对一组SARS-CoV-2变种的抗体中和的评估.
  • 耗尽实验,以确定初始变体暴露对抗体特异性的影响.

主要成果:

  • 暴露于两种抗原上不同的变体 (例如,前Omicron之后Omicron) 增加了抗体中和幅度.
  • 针对与人体冠状病毒SARS-CoV.密切相关的人类冠状病毒,没有引发显著的交叉中和.
  • 抗体特异性受到第一个变体暴露的强烈影响,第二次暴露主要扩大了交叉反应性抗体,而不是诱导新的变体特异性反应.

结论:

  • 多次暴露于SARS-CoV-2增强了对各种变体的交叉中和,证明了扩大免疫力.
  • 免疫印记的现象是显而易见的,在这种情况下,初始暴露决定了对随后的变种遭遇的抗体反应概况.
  • 在先前暴露后,对最近遇到的SARS-CoV-2变体进行de novo抗体生产的能力有限.