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评估副作用的烦,负担和耐受性:一项定性研究,探讨癌症治疗功能评估的内容有效性 - 项目GP5
Nalin Payakachat1, Adrienne M Gilligan1, Danielle Altman2
1Eli Lilly and Company, Indianapolis, IN, USA.
Journal of geriatric oncology
|July 5, 2025
概括
患者报告的副作用对癌症治疗耐受性至关重要. 癌症治疗的功能性评估 - 项目GP5 (GP5) 测量对甲状腺髓癌 (MTC) 患者来说是可以理解和相关的,得分为3或4表示高负担.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 定性研究是指质量研究.
背景情况:
- 患者报告的措施,如癌症治疗的功能评估 - 项目GP5 (GP5) 评估癌症治疗的耐受性.
- 在临床试验中使用GP5项目"我被治疗的副作用所困扰".
研究的目的:
- 探索甲状腺髓癌 (MTC) 患者如何构想副作用的烦,负担和耐受性.
- 收集支持GP5作为MTC治疗耐受性的适合目的措施的证据.
- 定义响应选项,这意味着"高副作用负担".
主要方法:
- 定性研究涉及40名来自LIBRETTO-531试验的MTC参与者的半结构面试.
- 使用诱导和演编码对采访成绩单进行主题分析.
- 概念诱导和认知采访,以评估GP5.5的理解和相关性.
主要成果:
- 副作用的烦是一个非常相关的概念,与MTC患者的治疗耐受性密切相关.
- 在GP5项目是明确和易懂的,与会者区分响应选项.
- 大多数参与者 (60%) 将"高副作用负担"与GP5分数3 ("相当") 和4 ("非常") 相关联.
结论:
- 副作用的烦,负担和耐受性是MTC患者的高度相关和相互关联的概念.
- 在GP5有效地捕捉了接受治疗的MTC患者的相关概念.
- 在GP5上得分为3或4恰当地反映了"高副作用负担",支持其在MTC治疗评估中的使用.
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