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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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优化Buffy外套聚合:通过基于血小板计数的分类来提高血小板产量.

Marco Amato1, Manfred Astl1, Lisa Seekircher2

  • 1Central Institute for Blood Transfusion and Immunology, University Hospital of Innsbruck, Innsbruck, Austria.

Transfusion medicine reviews
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PubMed
概括

通过捐赠者全血 (WB) 血小板计数对抗性外套 (BCs) 进行分类,可显著增加血小板产量和产品标准化. 这种方法增强了双剂量血小板缩剂的生产,提高了血液制品制造的效率.

关键词:
巴菲的外套.这是一种双剂量治疗.效率 效率 效率 效率 效率 效率 效率病原体无活化 病原体无活化血小板计数 血小板计数 血小板计数 血小板计数聚合 聚合 聚合 聚合 聚合排序 分类 排序

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科学领域:

  • 输血医学 输血医学
  • 血液学 血液学 血液学
  • 生物技术是生物技术.

背景情况:

  • 在聚合布菲外套 (BC) 衍生的血小板产品中优化血小板产量对于高效的血液储存至关重要.
  • 供体全血 (WB) 血小板数量的变化会影响血小板度产量的一致性.
  • 预选择算法可能会改善血小板生产的标准化.

研究的目的:

  • 根据捐赠者全血 (WB) 血小板计数,评估分类保鲜衣 (BC) 的有效性.
  • 为了比较随机BC聚合与算法排序的BC聚合产生的血小板度的产量和可分割性.
  • 评估内部预选择算法对产生病原体失活的双剂量血小板缩剂的影响.

主要方法:

  • 两种BC聚合策略进行了比较:基于WB血小板计数的随机分配和分类,使用预选择算法.
  • 捐赠者WB血小板计数在聚合之前使用血液学分析仪测量.
  • 用威尔科克森排列和总和测试分析了被病原体无活化双剂量血小板缩物的产量和可分割率.

主要成果:

  • 根据WB血小板计数对BC进行排序,显著增加了血小板中位数度 (1247~1307×103/μL,P=0.0434).
  • 每个血小板单位的产量显著增加,从4.6到4.8×1011/单位 (P = .0191).
  • 可分割的病原体失活的血小板单位的比例从72.1%增加到89.5%.

结论:

  • 采用内部预选算法来根据WB血小板计数对BC进行排序,可以提高血小板度的产量.
  • 这种分类方法导致更标准化的血小板产品,具有更好的可分割率.
  • 基于算法的方法是有效的生产高质量的,双剂量的血小板缩剂.