年龄对血管风险因素与急性中风 (INTERSTROKE) 的关联的影响:一个病例对照研究
Catriona Reddin1, Graeme J Hankey2, John Ferguson3
1HRB Clinical Research Facility Galway, University of Galway-University Hospital, Galway, Ireland; Wellcome Trust-HRB, Irish Clinical Academic Training, Dublin, Ireland.
血管风险因素对中风的影响随着年龄的增长而有很大变化. 了解这些特定年龄的关联对于优先考虑减少中风负担的干预措施至关重要.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 心血管医学 心血管医学
背景情况:
- 由于人口老龄化和年轻成年人发病率增加,全球中风负担正在上升.
- 在INTERSTROKE研究中,研究了年龄如何影响血管风险因素和中风之间的关系.
研究的目的:
- 为了确定年龄是否改变了血管风险因素和中风之间的关联.
- 分析血管风险因子患病率的特定年龄模式及其对中风风险的影响.
主要方法:
- 一项国际病例控制研究,涉及32个国家的26,950名参与者.
- 在不同年龄组中分析了血管风险因素及其人口归因分数 (PAFs).
- 使用统计测试来评估年龄和每个风险因素之间的相互作用.
主要成果:
- 年龄的增加与高血压,身体不活动,糖尿病,心房动,高腰比,高阿波利波蛋白B和肥胖症的更高患病率相关.
- 与高血压,高腰比,酒精使用和心理社会压力相关的中风风险大小随着年龄的增长而下降.
- 高血压,高腰部和部比率以及身体不活动是所有年龄段中风风险的最重要因素.
结论:
- 血管风险因素和中风之间的关联在各个年龄组之间有所不同.
- 根据年龄量身定制风险因素查和修改策略,可以帮助优先考虑干预措施,减少中风发生率.
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