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关于胆囊癌的遗传,表观遗传和转录基因基础的全球视角

Doutrina Das¹, Pooja Singh¹, Manjusha Pal²

¹Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

Critical reviews in oncology/hematology

|July 5, 2025

概括

胆囊癌 (GBC) 涉及遗传,表观遗传和转录基因的变化. 目前正在进行研究,以寻找可用于早期检测的生物标志物,并为这种侵袭性癌症提供更好的治疗结果.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一种遗传学.

背景情况:

胆囊癌 (GBC) 是一种具有不良预后的攻击性恶性瘤.
它的发展受到环境,微生物和生理因素的影响.
遗传,表观遗传和转录基因变异在GBC病变发生过程中越来越多地被认可.

研究的目的:

审查胆囊癌 (GBC) 患者的分子变化.
综合当前关于GBC遗传,表观遗传和转录基因变化的知识.
要突出这些分子变化在GBC发育中的作用.

主要方法:

在主要的科学数据库 (PubMed,Scopus,EMBASE,Google Scholar) 进行了全面的文献搜索.
审查中包括了2025年5月之前发表的研究.
总共分析了248项相关研究.

主要成果:

确定了24个与GBC相关的基因,影响了细胞亡,细胞循环,DNA修复和细胞粘附.
转录组分析显示了编码和非编码RNA的变化,突出了基于RNA的调节网络.
表观遗传修饰,包括DNA甲基化,基因素乙化和miRNA调节,影响关键的细胞过程,如DNA修复和亡.

结论:

由于非特异性症状,GBC通常被诊断为晚期,从而使早期检测复杂化.
目前缺乏用于早期GBC诊断的可靠生物标志物.
未来的研究重点是发现生物标志物,以实现早期诊断和改善治疗策略.

关键词:

细胞循环调节器细胞循环调节器表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.胆囊癌是一种胆囊癌.遗传多形态的遗传多形态.遗传学遗传学是一种遗传学.国家储备系统 (NGS)瘤基因是一种瘤基因.文字转录学 (Transcriptomics) 是一个学科.瘤抑制基因的基因

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