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由内皮激活和压力指数 (EASIX) 评估的内皮功能障碍预测慢性心力衰竭患者的死亡风险
Bent Estler1, Hanna Fröhlich1, Tobias Täger1
1Department of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
International journal of cardiology
|July 5, 2025
概括
内皮激活和压力指数 (EASIX) 可以预测慢性心力衰竭患者的死亡风险. 这种从常规实验室测试中计算的新型生物标志物为心血管疾病管理提供了有价值的预后信息.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 预测医学是一种预测医学.
背景情况:
- 内皮功能障碍是慢性心力衰竭 (CHF) 的标志,但缺乏常规量化.
- 内皮激活和压力指数 (EASIX) 使用肌,乳酸脱酶和血小板来预测各种条件下的结果.
- EASIX在诸如全源干细胞移植,COVID-19和冠状动脉疾病等疾病中显示出预后价值.
研究的目的:
- 在慢性心力衰竭 (CHF) 患者中调查内皮细胞激活和压力指数 (EASIX) 的预后效用.
- 确定EASIX是否可以作为预测CHF患者死亡风险的新生物标志物.
主要方法:
- 使用来自CHF注册的培训 (n=1796) 和验证 (n=1796) 队列.
- 使用多变量考克斯回归评估了五年总生存期,并对临床共变量进行了调整.
- 采用了非线性关系的分数多项式,并通过布里尔分数和一致性指数评估了预后性能.
主要成果:
- EASIX与NT-proBNP,NYHA阶段和LVEF显示出中度的相关性.
- 增加的EASIX水平与两个队列中的死亡风险显著增加有关 (HR每日志2增加:1.51-1.59).
- 预先确定的EASIX截止值独立预测死亡风险增加 (HRs从2.14到3.34不等).
结论:
- 内皮激活和压力指数 (EASIX) 是一种新且有效的生物标志物,用于预测慢性心力衰竭 (CHF) 患者的死亡风险.
- EASIX提供独立的预后信息,在各种心力衰竭病因和阶段中一致.
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