相关实验视频

Updated: Sep 16, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

一种用于长效癌症治疗的药物储存策略,使用形态转换的两性聚合物纳米粒子进行长效治疗

Jiao Sun¹, Yiqing Wang², Jiaxing Zhang²

¹School of Materials Science & Engineering, Changzhou University, Changzhou, Jiangsu, 213164, China.

Acta biomaterialia

|July 5, 2025

概括

这项研究开发了一种pH响应性聚合物 (LPHF),作为瘤特异性药物储存器. 它沉积在瘤中,释放含有药物的纳米粒子,并通过改善药物积累和减少剂量频率来增强癌症治疗.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
药物运输药物运输药物运输

背景情况:

瘤的细胞外屏障阻碍了药物积累,需要频繁的剂量.
重复使用药物可能会导致血液清理加速 (ABC),从而降低治疗效果.

研究的目的:

开发一种使用两聚合物 (LPHF) 的新型药物储备战略,以克服癌症治疗中的药物输送挑战.
创建一个响应pH的系统,将药物沉积定位在瘤中,并使可控释放成为可能.

主要方法:

一种两性聚合物 (LPHF) 被合成,具有可调节的水友性和形态转换能力.
在pH 7.4时LPHF自组装成纳米粒子 (LPHF@Dox),在pH 6.5时过渡到沉积状态.
在瘤微环境中,依赖于pH值的LPHF水解引发了纳米粒子复制 (LPHF@DoxRC) 与电荷逆转和叶酸结合.

主要成果:

在pH 6.5.5下,LPHF@Dox系统有效地转化为瘤特异性药物储存库.
在瘤微环境中LPHF的水解导致重新构成的纳米颗粒的释放 (LPHF@DoxRC).
复制的纳米颗粒显示电荷逆转和增强的细胞内化和瘤透由于叶酸结合.

结论:

开发的LPHF系统作为一个智能,瘤特异性药物储存库,为有效的癌症治疗提供了一种新方法.
该策略解决了重复剂量和ABC效应的局限性,可能提高治疗疗效.
局部药物保留的双相方法,其次是受控释放,为长期起作用的癌症治疗提供了一个有希望的策略,副作用减少.

关键词:

两性聚合物两性聚合物癌症治疗治疗癌症治疗药物储备库是药物储备库.水友性和疏水性是水友性和疏水性.形态转变的形态转变

更多相关视频

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

相关概念视频

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Drug Distribution: Tissue Binding

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...