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肠道微生物群调节的进展和机制在增强免疫检查点抑制剂疗效方面
Li Chen1, Baoyi Li2, Menghang Zu2
1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China; State Key Laboratory of Resource Insects, College of Sericulture, Textile, and Biomass Sciences, Southwest University, Chongqing 400715, China.
肠道微生物群显著影响免疫检查点抑制剂 (ICI) 的癌症免疫疗法的有效性. 通过移植或饮食等干预措施调节肠道微生物可以改善治疗结果并减少副作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 肠道微生物群在免疫和代谢健康中起着至关重要的作用.
- 免疫检查点抑制剂 (ICI) 是关键的癌症疗法,但面临的挑战是耐药性和不良事件.
- 肠道微生物群的组成越来越被认为是影响ICI疗效的因素.
研究的目的:
- 审查肠道微生物群调节策略如何可以增强ICI治疗.
- 探索肠道微生物影响免疫反应和ICI结果的机制.
- 为基于微生物群的个性化癌症免疫疗法提供基础.
主要方法:
- 系统审查临床前小鼠模型和临床试验.
- 对各种肠道微生物群调节策略的分析:便微生物群移植,特定微生物补充剂,饮食/生活方式干预以及前/后生物补充剂.
- 检查涉及微生物转移,代谢物和细胞外囊泡的机械途径.
主要成果:
- 肠道微生物群调节策略显示出改善ICI治疗结果的潜力.
- 这些干预措施也可能有助于减轻与免疫相关的不良事件 (irAEs).
- 机制包括塑造宿主免疫 (先天性,适应性,粘膜) 和影响免疫检查点表达.
结论:
- 肠道微生物群是ICI疗效和毒性的关键决定因素.
- 针对性调节肠道微生物群为优化癌症免疫治疗提供了一个有希望的途径.
- 基于微生物群的个性化策略对于未来的癌症治疗至关重要.
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