结膜生物标志物C-反应蛋白和calprotectin用于诊断慢性周围假肢关节感染:未来的多中心评估
Louise Ruffier d'Epenoux1, Manon Robert2, Raphaël Lecomte3
1Service de Bactériologie et des Contrôles Microbiologiques, CHU Nantes, Nantes, France; INSERM, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, Nantes Université, Nantes, France; Membre du CRIOGO (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest), Nantes, France.
The Journal of arthroplasty
|July 5, 2025
概括
突性calprotectin和C-反应蛋白 (CRP) 显示在诊断周围假肢关节感染 (PJI) 时具有很高的准确性. 这些具有成本效益的生物标志物可能会改善PJI诊断算法.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 周围假肢关节感染 (PJI) 的诊断是具有挑战性的.
- 突液 (SF) 分析对于PJI诊断至关重要.
- 像α-defensin (AD) 这样的现有生物标志物是有效的,但成本高昂.
研究的目的:
- 为了评估PJI的突性calprotectin和CRP的诊断性能.
- 评估这些生物标志物作为PJI诊断的低成本替代品.
主要方法:
- 一项前性多中心研究,包括157名接受关节或膝关节假肢切除的患者.
- 测量了同胞液中calprotectin和CRP水平.
- 根据多学科会议,患者被分类为感染者 (PJI) 或非感染者 (非PJI).
主要成果:
- 突性calprotectin的灵敏度为94.23%,特异性为78.26%.
- 综合性CRP敏感度: 80.77%,特异性: 86.96% .
- 这两种生物标志物都表现出PJI的高诊断准确性.
结论:
- 突性calprotectin和CRP测定显示出PJI诊断的卓越准确性.
- 这些生物标志物是PJI诊断算法的有希望的,具有成本效益的补充.
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