对持续的CRP升高与轴性脊柱关节炎中的内皮功能障碍之间的关系的分子见解
Laura Cuesta-López1, Iván Arias-de la Rosa2,3,4, Jesús Eduardo Martín-Salazar5
1University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia Hospital, Cordoba, Spain.
RMD open
|July 5, 2025
概括
在轴性脊椎关节炎 (axSpA) 患者中,持续高C反应蛋白 (CRP) 显著增加心血管风险,内皮功能障碍和动脉样硬化. 针对炎症的疗法,如抗瘤缩因子-α,可以减轻这些风险.
科学领域:
- 风湿病学和免疫学
- 心血管医学 心血管医学
- 分子生物学分子生物学
背景情况:
- 轴性脊椎关节炎 (axSpA) 与心血管 (CV) 风险增加有关.
- 慢性炎症在动脉样硬化的发病过程中起着关键作用.
- 持续的C-反应蛋白 (CRP) 升高对axSpA中的心血管风险因素的影响需要进一步阐明.
研究的目的:
- 研究持续CRP升高对axSpA患者心血管风险因素的影响.
- 探索 axSpA 中的分子机制,将炎症与内皮功能障碍和动脉样硬化联系起来.
- 评估抗瘤缩因子-α (抗TNF-α) 治疗对这些参数的影响.
主要方法:
- 评估了245名axSpA患者的心脏内膜介质厚度 (CIMT) 和微血管内皮功能.
- 根据持续高CRP水平 (超过5年50%的升高读数) 来对患者进行分类.
- 进行了184种蛋白质的蛋白质组分析和体外研究.
主要成果:
- 在40%的患者中观察到持续的CRP升高,与增加的代谢并发症,动脉样硬化斑块和内皮功能受损相关.
- 鉴定出介质素-6 (IL-6) 和含有CUB域的蛋白-1 (CDCP-1) 是内皮功能障碍和动脉样硬化的关键媒介.
- 偏氧酶3 (PON-3) 呈现出保护作用,而抗TNF-α疗法改善了代谢/炎症概况和调节关键蛋白水平.
结论:
- 持续的CRP升高是axSpA中心血管风险增加的重要预测因素.
- 在 axSpA 中,IL-6,CDCP-1 和 PON-3 是炎症-动脉样硬化轴中的关键分子参与者.
- 抗TNF-α疗法通过改善axSpA患者的炎症和代谢概况,显示出在控制心血管风险方面的潜力.
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