间歇运动和日间变化的影响体育相关脑震荡的血液生物标志物:一个交叉队列研究
Linden C Penner1, Jason B Tabor1, Joel S Burma1
1Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Canada.
运动短暂地降低了关键的脑损伤生物标志物,神经丝光和状纤维酸性蛋白质,在运动后立即. 每天的变化也会影响总水平,因此对脑震荡生物标志物研究需要谨慎的时间安排.
科学领域:
- 运动生理学 运动生理学
- 神经科学是一个神经科学.
- 生物标志物研究的研究.
背景情况:
- 精确测量脑震荡生物标志物对于诊断和管理至关重要.
- 了解影响生物标志物水平的因素,如运动和一天中的时间,至关重要.
- 以前的研究还没有完全阐明急性运动对特定血生物标志物的影响.
研究的目的:
- 为了研究不同强度的运动对神经丝光 (NFL),质纤维酸蛋白 (GFAP),ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) 和总tau的血度的影响.
- 检查这些生物标志物的日间变化.
- 为未来的脑震荡生物标志物研究协议提供信息.
主要方法:
- 一项观察性交叉队列研究,涉及10名参与者 (7名女性,3名男性).
- 参与者完成了三个随机的运动条件:控制,中等强度间歇训练和高强度间歇训练.
- 血样本在每次运动条件之前,期间和每次运动条件后最多48小时内在多个时间点收集.
主要成果:
- 神经纤维光 (NFL) 在中度和高强度间歇运动后立即显示过渡性下降.
- 质纤维酸蛋白 (GFAP) 也在运动后立即下降,在1小时内恢复到基线水平.
- 在所有运动条件下,总的tau水平在一天内下降.
结论:
- 急性炼可能会导致血NFL和GFAP水平的即时,暂时变化.
- 每天的变化会影响的总度,这凸显了标准化采血时间的重要性.
- 这些发现强调了在设计与运动相关的脑震荡生物标志物研究时需要考虑运动和日间影响.
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