多王国微生物群分析揭示了IBS与抑郁症和焦虑症的细菌病毒相互作用
Qin Liu1,2, Wenyu Fang3,4, Ping Zheng3,4
1Centre for Chinese Herbal Medicine Drug Development, Hong Kong Baptist University, Hong Kong SAR, China. qinliu@hkbu.edu.hk.
NPJ biofilms and microbiomes
|July 5, 2025
概括
刺激性肠综合征 (IBS) 涉及改变的肠道微生物群和细菌菌体. 肠道病毒显著预测IBS患者的精神问题,揭示了它们在肠道生态系统中的关键作用.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 病毒学 病毒学
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的胃肠疾病,通常与心理症状有关.
- 肠道细菌微生物群影响免疫力,其变化与IBS有关.
- 其他肠道生物体,如菌体在IBS中的作用仍然不清楚.
研究的目的:
- 为了分析360名IBS患者的多王国肠道微生物群.
- 研究肠道微生物群,IBS和心理状况之间的关系.
- 确定菌体在IBS病变发生过程中的作用.
主要方法:
- 具有心理表型的前性队列研究.
- 使用多原子数据进行多王国微生物群分析.
- 机器学习用于预测精神病相关疾病.
主要成果:
- 与对照组相比,IBS患者的社区内微生物相关性较低.
- 独特的微生物种群模式与IBS和精神障碍有关.
- 肠道病毒,特别是菌体,是精神病并发症的显著预测因素 (AUC 0.78).
- 在IBS中,lysogenic菌体具有更广泛的宿主范围;Bilophia有丰富的菌体.
- 患有抑郁症的IBS患者有更多的病毒代谢基因参与硫代谢和乌比金生物合成.
结论:
- 肠道病毒在IBS的病理生理学中发挥着关键作用.
- 菌体是IBS患者肠道微生物组的重要贡献者.
- 了解IBS中的病毒-细菌相互作用对于疾病管理至关重要.
相关概念视频
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Altered...
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01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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01:17Drugs for Treatment of Diarrhea-Predominant IBS
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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01:29Bacterial Flora of the Large Intestine
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The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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