职位空缺对来自尼罗河鱼骨粉的蓝色酸支架的影响
Atchara Khamkongkaeo1,2, Amaraporn Wongrakpanich3, Theerapat Chanamuangkon4
1Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Wangmai, Pathumwan, Bangkok, 10330, Thailand.
Scientific reports
|July 5, 2025
概括
这项研究使用海绵复制技术从商业和鱼骨来源制造了多孔酸 (HAp) 支架. 鱼骨支架显示出独特的蓝色色调和良好的生物相容性,适合骨组织工程.
科学领域:
- 生物材料科学 生物材料科学
- 陶工程 陶工程 陶工程
- 组织工程是组织工程.
背景情况:
- 多孔酸支架对于骨再生至关重要.
- 开发具有成本效益和生物相容性脚手架材料至关重要.
- 尼罗河鱼鱼骨提供了酸的潜在来源.
研究的目的:
- 为了制造和表征从商业酸 (SA-P) 和尼罗河骨衍生 (FB-P) 粉末的多孔陶支架.
- 为了评估烧结温度对脚手架性能的影响.
- 评估制造的脚手架的体外生物相容性和生物活性.
主要方法:
- 聚氨海绵复制技术用于脚手架制造.
- 在1300°C和1400°C下烧结5小时.
- 使用FTIR,XRD,UV-vis,XANES和体外细胞毒性试验进行了表征.
主要成果:
- 脚手架呈现出高孔度 (70-90%) 和相互连接的孔隙.
- 由于HAp中的氧和氧空缺,FB支架呈现出蓝色的颜色.
- 与FB支架相比,SA支架显示出更高的细胞活力和增殖.
- 两种脚手架类型都证实了生物相容性,FB脚手架适用于骨组织工程.
结论:
- 聚氨海绵复制技术有效地产生多孔的HAp支架.
- 烧结温度会影响脚手架的相位组成和特性.
- FB支架为骨组织工程应用提供了一个有希望的,生物相容的替代方案.
- 优化OH-空位和HAp/β-TCP组成可以提高脚手架的生物性能.
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